CCNE1 and Hodgkins lymphoma: In classical Hodgkin lymphoma, CCNE over-expression seems to reflect profound deregulation of the cell cycle in Hodgkin and Reed-Sternberg cells (Tzankov et al. 2003b; Tzankov et al. 2005b) and has no prognostic significance, while CCNE in DLBCL obviously preserves its oncogenic potential to promote G1-S transition independent of extracellular mitogenic stimuli (Gong et al. 1995; Bortner and Rosenberg 1997).