BCL2 and diffuse large B-cell lymphoma: Indeed, in the absence of BCL-2 translocation, amplification of 18q21 (containing the BCL2 gene) is another important mechanism for bcl-2 protein over-expression in DLBCL, and can be detected in about 30% of cases (Monni et al. 1997; Rao et al. 1998; Skinnider et al. 1999; Rantanen et al. 2001).