A large proportion of CD10+ DLBCL express Bcl-6 (Fig. 3), indicating a GC-origin, and this phenotype seems to be particularly predictive of a favorable outcome (Ree et al. 2001; Barrans et al. 2002b; Colomo et al. 2003; Huang et al. 2002; McCluggage et al. 2002; Tzankov et al. 2003a; Chang et al. 2004; Hans et al. 2004; Zinzani et al. 2005; Berglund et al. 2005; van Imhoff et al. 2006). Here, BCL6 is linked to diffuse large B-cell lymphoma.