TP53 and diffuse large B-cell lymphoma: Some studies showed that the p53+/p21− (Δp53) immunophenotype, used as a surrogate for p53 mutations, is associated with treatment failure and poor survival in DLBCL as well, particularly in GC DLBCL (Moller et al. 1999; Pagano et al. 2001; Visco et al. 2006).