BCL2 and diffuse large B-cell lymphoma: There is no evidence that the presence of a BCL-2 translocation at diagnosis has any impact on the survival of patients with DLBCL, though the prognostic impact of bcl-2 protein expression, evaluated in multiple large-scale trials, is significant (Hill et al. 1996; Gascoyne et al. 1997a; Pescarmona et al. 1997; Bebb et al. 2002; Muris et al. 2006b).