CCNE1 and diffuse large B-cell lymphoma: In addition to the direct activation of CDK4, CCND3 can further promote cell proliferation by the sequestration of p27 and indirect activation of CDK2/CCNE, which might explain why high p27 expression (probably sequestered by CCND3) is an adverse prognostic factor in DLBCL (Saez et al. 1999; Sanchez-Beato et al. 1999; Lin et al. 2003).