The exemplary t(14;18) (q32; q21) translocation characteristic of follicular lymphoma (Tsujimoto et al. 1985), which induces production of high levels of bcl-2 protein, is observed in about 25% of DLBCL, but bcl-2 protein expression is found in >50% of DLBCL (Fig. 3) (Jacobson et al. 1993; Piris et al. 1994; Dalla-Favera et al. 1994; Gascoyne et al. 1997a; Pescarmona et al. 1997; Kramer et al. 1998; Skinnider et al. 1999; Rantanen et al. 2001; Huang et al. 2002; McCluggage et al. 2002; de Leval and Harris 2003; Barrans et al. 2003; Tzankov et al. 2003a; Iqbal et al 2004). The gene discussed is BCL2; the disease is follicular lymphoma.