While bcl-6 protein or mRNA expression in DLBCL has been found to predict favorable outcomes by some investigators, this has not been confirmed by others (Lossos et al. 2001; Braaten et al. 2003; Colomo et al. 2003; Tzankov et al. 2003a; Chang et al. 2004; Winter et al. 2006). The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.