Considering cell cycle regulation in DLBCL, expression of CCNB1, CCND2, CCND3, CCNE, CDK1 and CDK2 and CDKI p27 have been shown to be prognostically relevant (Erlanson et al. 1998; Saez et al. 1999; Sanchez-Beato et al. 1999; Ferreri et al. 2001; Moller et al. 2001; Filipits et al. 2002; Kuttler et al. 2002; Lin et al. 2003; Saez et al. 2004; Hans et al. 2005; Obermann et al. 2005b; Tzankov et al. 2006). This evidence concerns the gene CCNB1 and diffuse large B-cell lymphoma.