Bcl-6 expression in DLBCL may be a signature of a GC differentiation stage of the original B-cell before malignant transformation, or may be turned on due to translocations involving the BCL6 locus at 3q27 with variable partners of either the Ig family or non-Ig genes, or due to mutations in the 5′ non-translated regulatory region (Ye et al. 1993; Lo Coco et al. 1994; Ye et al. 1995; Pescarmona et al. 1997; Kramer et al. 1998; Skinnider et al. 1999; Capello et al. 2000; Butler et al. 2002; Falini and Mason, 2002; Pasqualucci et al. 2003; Ohno, 2006). This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.