Studies on the molecular mechanisms underlying FOXP1 expression in both DLBCL and MZL showed that its expression can result from a translocation t(3;14) (p13; q32) in 1% of cases, or may be related to an increased gene copy number, since 60% of FOXP1+ DLBCL harbor the trisomy 3 (Wlodarska et al. 2005; Fenton et al. 2006). Here, FOXP1 is linked to marginal zone lymphoma.