Considering the expression of bcl-6, CD10 and MUM1 as well as CD44, CD138, bcl-2 and other biomarkers, different algorithms to identify GC and non-CG DLBCL have been proposed (e.g. Barrans et al. 2002b; Colomo et al. 2003; Tzankov et al. 2003a; Chang et al. 2004; Hans et al. 2004; Zinzani et al. 2005, Tzankov et al. 2006; Muris et al. 2006b; Oh et al. 2006; van Imhoff et al. 2006), but confirming the relevance of most of them is hampered by failures in results reproducibility and low validity. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.