These data also show the vital role that ICAM-1 plays not only in initiating tumor-mesothelium adhesion, but also in preparing the right environment for subsequent invasion despite some published data suggesting that the up-regulation of ICAM-1 inhibit tumor progression and indicate a better prognosis (Maeda et al. 2002; Tachimori et al. 2005). Here, ICAM1 is linked to neoplasm.