Factors like serum-soluble intercellular adhesion molecule-1(ICAM-1) [3] and CEA levels, T stage, but not the mediastinal lymph node diameter on CT scan [4], expression of Caveolin-1, a tumor suppressor [5], and amplification of c-myc gene [6] have all been found to correlate with the presence of N2 disease, some of them also implying worse prognosis after surgery. The gene discussed is ICAM1; the disease is neoplasm.