In view of the recent data of our group regarding the role of laminin receptors in tumor invasion and metastasis via activation of MMP-2 synthesis in malignant melanoma (Givant-Horwitz, 2004), it is conceivable that integrins, rather than the 67kDa receptor, may contribute to MMP production following binding to laminin in MM. This evidence concerns the gene LAMB2 and Miyoshi myopathy.