IGF1 and Miyoshi myopathy: MMP expression and secretion by MM cells in vitro is increased by several growth factors, including HGF/SF (Harvey, 2000; Liu, 2003), epidermal growth factor (EGF), acidic and basic fibroblast growth factor (aFGF, bFGF), insulin-like growth factors I and II (IGF-I,II) and transforming growth factor-α (TGF- α) (Liu, 2003).