Additional pro-angiogenic molecules and growth factors that are synthesized by MM cell lines and clinical specimens are interleukin-8 (IL-8) (Galffy, 1999; Davidson, 2004), bFGF (Strizzi, 2001b; Davidson, 2004), TGF-α (Langerak, 1996), IGF (Hoang, 2004a), heparanase (Davidson, 2004), thrombospondin (Ohta, 1999b), HGF/SF (Klominek, 1998b; Thirkettle, 2000) and several members of the Syndecan proteoglycan family (Kumar-Singh, 1998; Gulyas, 2003). Here, IGF1 is linked to Miyoshi myopathy.