Recent studies suggest that TIMP-1 has prognostic value in head and neck SCC (Ruokolainen et al. 2005a), colorectal carcinoma (Holten-Andersen et al. 2000), ovarian carcinoma (Rauvala et al. 2005) and breast carcinoma (Talvensaari-Mattila et al. 2005a). Here, TIMP1 is linked to breast carcinoma.