Similarly, another group has also investigated the DNA methylation status of various apoptosis-associated genes (DAPK, BCL2, TERT, EDNRB, RASSF1A, and TNFRSF25) in urine sediments (Friedrich et al. 2004) and found that hypermethylation of the DAPK, BCL2, and TERT genes was highly sensitive (78%) and specific (100%) in detecting bladder cancer. This evidence concerns the gene DAPK1 and urinary bladder cancer.