The evaluation of the concentration of metalloproteinase-2 and its tissue inhibitor TIMP-2 in peripheral blood serum may be useful for the differentiation between benign and malignant thyroid tumors, but their concentrations in patients with thyroid cancer did not significantly correlate with the clinical staging of thyroid cancer (Pasieka et al. 2004). This evidence concerns the gene TIMP2 and thyroid gland carcinoma.