The vascular endothelial growth factor can also be detected in serum of patients with RA (Kikuchi et al. 1998; Harada et al. 1998), where vascular endothelial growth factor level is related to RA disease activity, therefore, suggesting that vascular endothelial growth factor may play some role in the pathogenesis of RA (Harada et al. 1998; Sone et al. 2001). The gene discussed is VEGFA; the disease is rheumatoid arthritis.