Some studies suggested that TRF-1 and TRF-2 were down-regulated in tumor tissues (Yamada et al. 2002; Saito et al. 2002; Yamada et al. 2000), whereas others showed that TRF-1 or TRF-2 was up-regulated (Oh et al. 2005; Nakanishi et al. 2003; Ancelin et al. 2002). The gene discussed is TERF2; the disease is neoplasm.