A number of genes are commonly hypermethylated in colorectal cancer (CRC) including hMLH1, p16INK4a, p14ARF, RAR-β, APC, MGMT, cyclin A1, CDX1, MYOD1, COX-2 and WT-1[21], [22], [23]. The gene discussed is RARB; the disease is colorectal cancer.