A more detailed prospective study in twenty patients who were observed longitudinally [3] showed significant differences in ten lymphocyte subsets associated with active MS and these markers included the innate and the adaptive arms, i.e. TCRαβ+CD4+CCR7−CD45RA− T-cells, TCRγδ+CCR5+ T-cells and regulatory T-cells. Here, CD4 is linked to myeloid sarcoma.