It remains to be shown whether co-expression of CD107a and CD127 reflects a general feature of T-cells with effector granules, or if the CD107a+CD127+ T-cell phenotype represents a CD4+ T-cell population associated with autoimmune diseases or chronic inflammatory processes: CD4+CD25− cells from patients with SLE were shown to be less sensitive to Treg activity as compared to T-cells from healthy controls [28]. This evidence concerns the gene CD4 and autoimmune disease.