The pathological hallmarks of these diseases include spongiform change of the neuropil and accumulation of misfolded forms (“PrPSc”, PrP-scrapie or “PrPD” to denote PrP-disease) of the cellular prion protein (PrPC), with some but not all aggregates being visible by light microscopy in the form of amyloid deposits detected with intercalating dyes or PrP-directed antibodies [2]. This evidence concerns the gene PRNP and scrapie.