Recently, we demonstrated that binding of GnRH-I (a classical form of GnRH) and GnRH-II (a second form of GnRH) to the GnRH-I receptor activates ERK1/2 through a PKC-dependent pathway and is essential for GnRH-induced anti-proliferation of ovarian cancer cells [20]. This evidence concerns the gene GNRH2 and ovarian cancer.