It is of interest that GnRH-II induced much greater expression of pERK1/2 or pp38 in these cells compared to GnRH-I, suggesting that GnRH-II may have a greater effect on the activation of pERK1/2 or pp38 compared to that of GnRH-I in HEC1A endometrial cancer cells. This evidence concerns the gene GNRH1 and endometrial cancer.