GNRH1 and female reproductive organ cancer: In addition to reproductive roles of GnRH in hypo-pituitary ovarian (HPO) axis, GnRH-I, a classical form of GnRH, has an inhibitory effect on cell growth in human mammary, ovarian, endometrial, and prostate tumors and has been implicated as an antiproliferative factor of gynecologic cancers [4-8].