The large tumor suppressor (Lats)/Warts (wts) gene is conserved from insect to humans and codes for a serine/threonine kinase that was successively implicated as a tumor suppressor, a regulator of mitosis and a key component of the so-called Hippo pathway that controls the coordination between cell proliferation and apoptosis (reviewed in [1,2]). Here, LATS1 is linked to neoplasm.