Moreover, we have shown in our laboratory that TGF-β isoforms efficiently inhibit cellular proliferation in human endometrial carcinoma cell lines and that TGF-β3 increases invasiveness of endometrial carcinoma cells through PI 3-K upregulation of XIAP and protein kinase C induction of MMP-9 [33]. The gene discussed is TGFB3; the disease is endometrial carcinoma.