There was no relationship between the serum hepcidin-25 level and the histological grade of RCC (mean ± S.D., grade 1, 17.02 ± 10.32; grade 2, 43.37 ± 40.04; grade 3, 35.58 ± 37.78, P = 0.1492, Figure 1A), or the tumor stage (pT1–2, 26.21 ± 14.58; pT3–4, 50.75 ± 50.04, P = 0.0719, Figure 1B). This evidence concerns the gene HAMP and renal cell carcinoma.