A higher serum CRP level was associated with poorly differentiated RCC (grade 1, 0.10 ± 0.01; grade 2, 1.32 ± 2.33; grade 3, 2.56 ± 2.59, P = 0.0036), local invasion (pT1–2, 0.43 ± 0.90; pT3–4, 2.52 ± 2.86, P = 0.0014), and metastatic disease (M1, 3.45 ± 3.15; M0, 0.52 ± 0.92, P = 0.0004). This evidence concerns the gene CRP and renal cell carcinoma.