Expression trends in key apoptosis genes along the AKT/p53 signaling axis (upregulation of transcriptional targets of FOXO3A: TNFRSF10B, GADD45A, GADD45B and FAS) and cytokine/chemokine receptors (downregulation of IL1R1, CCR2, CCR6, CD58 and CXCR3) mimic those observed in Tregs from T1D subjects, at one or more time-points. Here, CD58 is linked to type 1 diabetes mellitus.