The transcription factor FOXO3A as well as some its key pro-apoptotic transcriptional targets (GADD45A, GADD45B, SESN1, CDKN1B, CITED2 and TNFRSF10B) were upregulated in Tregs from T1D subjects. The gene discussed is CDKN1B; the disease is type 1 diabetes mellitus.