For reproducing expression signatures seen in Tregs from T1D subjects, we selected 32 key genes from the various functional clusters discussed so far (15 apoptosis-related genes, 11 cytokine & chemokine receptors and 6 GIMAP genes), and checked their expression trends in healthy Tregs, under conditions of IL-2 deprivation. The gene discussed is IL2; the disease is type 1 diabetes mellitus.