Further, in the gene-expression results, important cytokine-responsive lymphocyte activation markers: interleukin-2 receptor alpha (IL2RA), chemokine (C-C motif) receptor 5 (CCR5) and human leukocyte antigen, class II, DR alpha 1 (HLA-DRA1) were downregulated in Tregs from T1D subjects. The gene discussed is IL2RA; the disease is type 1 diabetes mellitus.