Moreover, injection of TLR2 KD-B16 cells into TLR2 deficient mice resulted in a further decrease in animal death (P<0.05, Fig. 6A), tumor cell metastasis and progression (Fig. 6B–E) compared to TLR2 deficient mice injected with the untreated B16 cells. The gene discussed is TLR2; the disease is neoplasm.