In particular, for men with G/A, G/G genotype in ESR2 38 bp 3′ of STP G>A, having a BMI of ≥30 kg/m2 was associated with a reduced the odds of developing prostate cancer by 57% compared to having a BMI of <25 kg/m2 (p-value for trend = 0.01) (Table 4). This evidence concerns the gene ESR2 and Familial prostate cancer.