ESR1 and Familial prostate cancer: Among the the group with low intake of phytoestrogen, men who had the variant homozygote G/G genotype in ESR1 Ex4-122C>G had a 5-fold increase in the odds of developing prostate cancer when compared with wild type homozygote C/C genotype (P = 0.02, p-value for trend = 0.04) (Table 3).