Among those who were diagnosed with advanced prostate cancer, associations between prostate cancer risk and genotypes were suggestive for four SNPs: ESR1 Ex1+392T>C, ESR1 IVS6+52G>T, ESR2 38 bp 3′ of STP G>A and ESR2 5659 bp 3′ of STP A>G. This evidence concerns the gene ESR1 and Familial prostate cancer.