When the corrected p value for over-inflated false positive rate [44], 0.0025 (0.05÷20), is applied to table 4, one interaction remains statistically significant: with ESR1 Ex1-192G>C (log likelihood ratio test: p = 0.0009<0.0025), suggesting that this SNP was a strong effect modifier on the association between dietary intake of phytoestrogen and prostate cancer risk. The gene discussed is ESR1; the disease is prostate carcinoma.