In addition, disruption of Scarb1 in chow-fed Apoe-deficient (Scarb1/Apoe double KO [dKO] mice) or Western diet-fed LDL receptor-deficient (Scarb1/Ldlr dKO) mice develop markedly accelerated atherosclerosis [8], [11], [12], demonstrating that elevated HDL and its atheroprotective effects are dissociated when reverse cholesterol transport (RCT) is impaired. This evidence concerns the gene LDLR and atherosclerosis.