Since some HAM/TSP patients are known to experience complications with other autoimmune disorders [5], [6], it would be of interest to determine if this newly defined T cell subset (THAM cells: IFN-γ+CCR4+Foxp3−CD4+CD25+ T cells) may also be abnormally increased and functionally deregulated in other immunological diseases. Here, CCR4 is linked to autoimmune disease.