Immunohistochemical analysis confirmed that in these tumours active caspase-3 was indeed mainly expressed by diverse non-epithelial cells and were almost M30 antigen-negative (Figure 1C, represented by Tumour 1), compared with other tumours in which epithelial cells were expressing most of the active caspase-3 and M30 antigen-positive (represented by tumour 2). Here, CASP3 is linked to neoplasm.