We found that the expression levels of seven integrin ligands (COL4A6, COL13A1, FGB, COL19A1, COL18A1, COL14A1, and COL11A2) were negatively correlated with the Gleason score, suggesting that the suppression of integrins and/or their ligands is associated with more advanced tumor grade. This evidence concerns the gene COL18A1 and neoplasm.