Interestingly, we found that 5 out of 26 cases (19.2%) WHO grade II astrocytomas are BCCIP negative, whereas 13/29 (44.8%) WHO grade III and 25/41 (60.1%) WHO grade IV astrocytomas are BCCIP negative (Figure 3). The gene discussed is BCCIP; the disease is astrocytoma (excluding glioblastoma).