CCNB1 and hepatocellular carcinoma: This gene was a known important mediator of inter-feron induced in cell growth inhibition and induction of cell death.19,20 1–8D was down-regulated in hepatocellular carcinoma, lung cancer and prostate cancer, while pro-growth genes such as cyclin B1 (CCNB1, 34736_at) was significantly up-regulated in three types of tumor samples.