As shown in Figure 1, 48% and 43% of isolates causing severe (SM) malaria and uncomplicated malaria (UCM) bound to wild type ICAM-1 (ICAM-1Ref), while the lesser amount of isolates could bind to mutant ICAM-1 proteins (ICAM-1Kilifi and ICAM-1S22/A) (ICAM-1Kilifi: 17% for SM and 21% for UCM; ICAM-1S22/A: 21% for SM and 17% for UCM). The gene discussed is ICAM1; the disease is malaria.