PRNP and scrapie: In contrast, two hamster PrP mutants (T215K and Q219K), whose corresponding MoPrP homologues do not support prion formation either in RML-seeded sPMCA reactions or in the ScN2a cell-culture model, could be readily converted into self-propagating PrPres in sPMCA reactions driven by Sc237 hamster scrapie.