RYR2 and diabetes mellitus: The greatest discrepancy was seen in the expression of ryanodine receptor 2 (RyR2), which was reported as 11.4-fold up-regulated in DM hearts by microarray analysis compared with a modest 1.19-fold by qRT-PCR (Table 4).The second major discrepancy was observed in the expression levels of GLUT4, which was reported as 1.30-fold up-regulated by microarray analysis compared with 0.21-fold down-regulation by qRT-PCR (Table 4) in DM samples.