The finding that a pool of Dp71 may act as a regulator of glutamatergic synapse maturation, architecture and function provides valuable insights into identifying some of the complex functional pathways underlying MR in DMD. Special interest should focus on factors and signals that coordinate the interplay between the pre- and postsynaptic compartments during synapse morphogenesis and plasticity, which appear involved in several types of mental disorders [15]. This evidence concerns the gene NR3C2 and psychiatric disorder.