AKT2 and breast carcinoma: Consistent with this interpretation, direct inhibition of Akt activity by the Akt inhibitors used here suppressed the invasiveness of HCC1937 cells more efficiently than EF1α downregulation and the specific Akt2 inhibitor was slightly more potent of the dual Akt1/Akt2 inhibitor, a finding in keeping with Akt1 and Akt2 having distinct roles in regulating the motility of breast cancer cells [11,31,32].