Bauer et al [63] examined the effect of an HSP90 inhibitor (17-allylamino-18-demethoxy-geldanamycin, 17-AAG) on KIT-expressing and imatinib-sensitive, KIT-expressing but imatinib-resistant and KIT-non-expressing and imatinib-resistant human GIST cell lines. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.