Schiessl on the other hand, found no differences in immunohistochemical expression of eNOS in the syncytiotrophoblast and extravillous trophoblast of placentas of normal controls and preeclamptic mothers, although placentas with IUGR show a decreased immunoreactivity and eNOS protein content, as estimated by Western blotting[119]. This evidence concerns the gene NOS3 and fetal growth restriction.