T. cruzi infection is associated with an upregulation of signalingpathways such as MAPKs, Notch and cyclin D, and reduced caveolin-1 expression.Adiponectin null mice have a cardiomyopathy and thus we speculate that the T. cruzi-inducedreduction in adiponectin contributes to the T. cruzi-induced cardiomyopathy. Here, CAV1 is linked to cardiomyopathy.