Thus, it is likely that in well-adapted systems there is some level of immune evasion and/or suppression, and this could explain why silencing some genes involved in immunity (LRIM1, CTL4) or oxidative stress (OXR1, GSTT1 and GSTT2) in An. gambiae (G3) females, has little effect on P. falciparum (3D7 strain) infection. The gene discussed is OXR1; the disease is infection.