In general, Anopheles gambiae is considered to be susceptible to P. berghei infection, because a high prevalence of infection can be achieved and parasites are only rarely melanized; however, silencing of either thioester-containing protein 1 (TEP1) [1], leucine-rich repeat immune protein 1 (LRIM1) [2], or LRIM2 (also called APL1, [3]), enhances P. berghei infection by 4–5 fold; indicating that, when these effector molecules are present, about 80% of parasites are eliminated by a lytic mechanism[1]. This evidence concerns the gene TEP1 and infection.