TNF and neoplasm: Compared with the 4T1 tumor-bearing Balb/c mice, significant increase in the levels of M-CSF (1.5 fold), IL-17 (1.5 fold), TNF-α, VegF, and IL-6 (1.2 fold) was observed in the 4T1 tumor-bearing arthritic mice (Figures 6e to 6g).