The infrequent (rate = 1) adverse events were, dyspepsia, plexus brachial pain, otalgia, increase of aspartate aminotransferase (ASAT), sweating, nausea, local sepsis, abulia, dyspnea, cardiac arrhythmia, and ocular pain. The gene discussed is ABCB7; the disease is cardiac arrhythmia.