CAV3 and cardiac hypertrophy: The influence of caveolin 3 on hypertrophy has been previously suggested by a number of evidences, including the development of cardiac hypertrophy in caveolin 3-null mice [39], the inhibition of agonist-induced cardiomyocyte hypertrophy by overexpression of caveolin 3 [40], and the observation that exercise training, preventing pathological hypertrophy in spontaneously hypertensive rats, is associated to the overexpression of caveolin 3 [41].