In the context of a potential role in TB pathogenesis, SIRPα is likely critical in the formation of multinucleate giant cells (as indicated by antibody blocking studies performed with in vitro models of giant cell formation [20], [21]) and in leukocyte trafficking via functional binding to the cell-associated ligand, CD47 [22], [23], [24]. The gene discussed is SIRPA; the disease is tuberculosis.