In vitro, auraptene also reduces superoxide generation in differentiated promyelocytic HL-60 cells [3], activates apoptotic pathways in Jurkat-T cells [4], suppresses MMPs in human colorectal adenocarcinoma cell line, HT-29 [18] and inhibits the expression of inducible nitric oxide and cyclooxygenase-2 in murine macrophage cell line RAW 264.7 [17,31]. This evidence concerns the gene DDIAS and colorectal adenocarcinoma.