PTGS2 and melanoma: In a randomized multi-institutional phase II trial including 76 mostly chemorefractory patients with progression of metastatic melanoma (stage IV melanoma according to AJCC criteria), we had observed a significantly prolonged progression-free survival in the group of patients that received angiostatically scheduled low-dose metronomic chemotherapy (trofosfamide) in combination with a PPARG agonist (pioglitazone) and a COX2 inhibitor (rofecoxib) compared to the group of patients who received metronomic chemotherapy alone [22].