PTEN inactivation was seen in 33 of 144 (22.9%) EOC's analyzed and was associated with histology subtype of clear cell and undifferentiated carcinomas (p = 0.0491); overexpression of p53 protein (p = .0413) and a trend was seen with older age (p = 0.0936). The gene discussed is TP53; the disease is carcinoma.