EGFR and head and neck squamous cell carcinoma: In addition to EGFR-targeted kinase inhibitors, inhibitors with broader target specificities are also in Phase II or III development for SCCHN including lapatinib (GlaxoSmithKline), which is a dual EGFR/HER2 inhibitor, and zactima (AstraZeneca), which targets VEGFR2 and RET in addition to EGFR (Table 1).