Cetuximab (Erbitux; ImClone Systems), a chimeric monoclonal IgG1 antibody directed against EGFR, was FDA-approved for the treatment of SCCHN in combination with RT for locally or regionally advanced disease and as a monotherapy for recurrent or metastatic SCCHN patients who have failed prior platinum-based therapy [6]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.