Here we also provide rationale for combining EGFR- and Src-targeted therapeutics for treatment of SCCHN, discuss published EGFR- and Src-combination treatment preclinical data, and summarize completed and ongoing clinical trials in solid tumors evaluating Src-targeted therapies in combination with EGFR-targeted therapies. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.