It is suggested that IGF-1 can produce an increased risk of intestinal cancer and fibrosis.[9] GH have shown a potential carcinogenic role in colorectal cancer,[10] primary Ki-1 lymphoma of the skin,[11] liposarcoma and lipoma,[12] hepatocarcinoma,[13] breast cancer,[14] prostate cancer[15] and uterine cervical cancer.[16] The trials regarding the usefulness of GH in IBD have not reported an increased incidence of cancer. This evidence concerns the gene GH1 and inflammatory bowel disease.