There is ample evidence in human IBD that the inflammatory cytokines such as IL-1 and IFN-γ are overexpressed and this finding correlates with reports of excessive amounts of NO produced by activated iNOS in lamina propria mononuclear cells and colon epithelial cells.[25, 28] This prompted us to investigate whether manipulation of cytokine profile by crocetin would lead to reduced NO activities, and thus decrease mucosal damage. The gene discussed is IFNG; the disease is inflammatory bowel disease.