On the other hand in a post-hoc analysis of the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI)-2 trial with 1181 patients no differences on cardiovascular mortality were observed, although metformin was associated with a significant lower rate of non-fatal MI and stroke as compared to sulfonylurea or insulin treatment [56]. This evidence concerns the gene INS and acute myocardial infarction.