Atherosclerosis was induced by double-balloon injury and a 9 month high-cholesterol diet and the rabbits were then randomized into 5 groups: continued high-cholesterol diet, normal-chow diet, normal-chow diet plus simvastatin, normal-chow plus L-805645 (a selective PPARγ agonist), and normal-chow plus simvastatin plus L-805645. This evidence concerns the gene PPARG and atherosclerosis.