EDA and glomerulosclerosis: Many studies have reported that the number of macrophages as revealed by immunostaining for ED1 increased remarkably in the remnant kidney of rats subjected to 5/6 nephrectomy [16, 18–20], and it was also observed that macrophage infiltration and proliferation occurs early (2–4 weeks after surgery), preceding the development of glomerulosclerosis and tubulointerstitial fibrosis [16, 18, 21].