Current NICE guidance for England and Wales [31], which although amended in response to judicial review since its original publication remains substantially the same in its effect, recommends that the three acetylcholinesterase inhibitors donepezil, galantamine and rivastigmine are used as options in the management of people with AD of moderate severity (MMSE score of between 10 and 20 points). Here, ACHE is linked to Alzheimer disease.