In order to validate whether a mutation in one of these genes might be responsible for OI, we genotyped three gene associated microsatellite markers derived from the surrounding genome sequence of COL1A1 (located on chromosome 9 (CFA 9) at 29.5 Mb) and COL1A2 (located on CFA 14 at 22.8 Mb), respectively. This evidence concerns the gene COL1A2 and osteogenesis imperfecta.