Whereas immunoreactivity of FOXO3a localized to the cytoplasm similarly in hippocampal neurons in control cases (Fig. 1A) as well as in cases of LBD (Fig. 1B), FOXO3a strongly and specifically localized to cortical Lewy bodies in all cases of pure LBD (Fig. 1C) and AD/LBD (Fig. 1D, case of age 64). Here, FOXO3 is linked to Alzheimer disease.