Tissue factor is highly expressed in metastatic, but not in non-metastatic breast carcinoma cells (Bluff et al, 2006), and may contribute to the metastatic process directly through the TF-FVIIa complex and/or through downstream generation of active coagulation factors (Booden et al, 2004; Palumbo et al, 2007). This evidence concerns the gene F3 and breast carcinoma.