VEGFA and invasive breast carcinoma: Moreover, the positive correlations seen in this study between VEGF expression and both MVD and proliferating ECs in hyperplasia, in situ and invasive breast carcinoma spectrum indicates that VEGF has a key role in breast cancer angiogenesis, most likely by binding to VEGF receptors on ECs and inducing EC proliferation (Ferrara et al, 2003).