Furthermore, TF-FVIIa signalling via PAR-2 has been shown to stimulate breast cancer cell migration (Jiang et al, 2004; Morris et al, 2006), and a humanised anti-TF monoclonal antibody (CNTO 859) inhibited experimental in vivo lung metastasis from invasive breast cancer cells by more than 99%, indicating a role for TF in breast cancer cell metastasis (Ngo et al, 2007). Here, TF is linked to breast carcinoma.